britishpainsociety.orgAt the base of the channel is the methyltransfer pore, which connects the pocket to the AdoMet-binding cleft.

diabetes.org.ukThe exception to the rule is the DOT1 family, members of which methylate K79 within the globular area of histone H3 and that are structurally not associated to SET-domain proteins 4 - 6 Current work means that SET-area-containing proteins methylate a few proteins along with histones (see later)