historyorb.comAs a constructing block for protein, amino acids like L-lysine are vital for normal development and growth. Min J, Zhang X, Cheng X, Grewal SI, Xu RM: Construction of the SET domain histone lysine methyltransferase Clr4.

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The exception to the rule is the DOT1 family, members of which methylate K79 in the globular region of histone H3 and which are structurally not related to SET-area proteins 4 - 6 Recent work means that SET-area-containing proteins methylate a few proteins in addition to histones (see later)