I have always had canines (they make a lot more C than 2 grams a day) I by no means saw a dog with a cold or flue. The exception to the rule is the DOT1 household, members of which methylate K79 within the globular area of histone H3 and that are structurally not related to SET-domain proteins four - 6 Current work suggests that SET-area-containing proteins methylate just a few proteins along with histones (see later)